Abstract
Aim.To study the associations between polymorphic variants of hemostasis protein-coding genes, hemostasis system functioning, and atherothrombosis development in patients with cardiovascular disease (CVD).Material and methods.The study included 76 patients. Polymorphic gene marker alleles were analyzed by PCRPDRF method.Results.The genotype prevalence was assessed for the polymorphic variants of F V, F II, Gp Iα, Gp IIIα, Gp Iβα, PAI-1, and FBG genes. In CVD patients, a polymorphic variant 4G (-675)5G of PAI-1 gene was associated with peripheral hemostasis disturbances.Conclusion.5G allele of PAI-1 gene was associated with higher plasminogen concentration and lower PAI-1 levels, which resulted in reduced plasma thrombogenicity.
Highlights
PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis
No Evidence of Association Between Prothrombotic Gene Polymorphisms and the Development of Acute Myocardial Infarction at a Young Age. Circulation 2003; 107: 1117
Summary
Атеротромбоз- (n = 37) 58,62 ± 12,52 22/15 противоречивы, к настоящему времени получены убедительные данные о существенном вкладе генетических особенностей системы гемостаза в формирование атеротромбозов у пациентов с ССЗ. Цель исследования — изучение ассоциации полиморфных вариантов генов, кодирующих белки системы гемостаза, с функциональными особенностями этой системы и развитием атеротромбоза у пациентов с ССЗ, жителей г.
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