Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia.

Natalia M. Okulova,Vyacheslav G. Morozov,Boris Klempa,Yulia V. Yunicheva,Evgeniy A. Tkachenko,Tamara K. Dzagurova,Galina P. Slyusareva,Aleksey Smirnov,Detlev H. Kruger

doi:10.3201/eid1404.071310

Natalia M. Okulova, Vyacheslav G. Morozov + Show 7 more

Open Access

https://doi.org/10.3201/eid1404.071310

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Abstract

Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.

Highlights

Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%
HFRS Cases Associated with DOBV Infections Altogether we characterized 126 patients with DOBV
DOBV circulation was found in the Sochi region, southern part of Russia

Summary

Introduction

Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients’ serum. 10,000–12,000 clinical cases of Puumala virus (PUUV) and DobravaBelgrade virus (DOBV) infection, mainly characterized by kidney failure, are reported from European Russia. In the Tula region, DOBV genetic material was detected in A. agrarius (striped field mouse), but not A. flavicollis, trapped in Kurkino village, a few kilometers from Tula city [11]

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