Hemorheology and hemostasis in stroke patients with type 2 diabetes and metabolic syndrome

Abstract

We present results of clinical and laboratory evaluation of acute stroke patients with type 2 diabetes and metabolic syndrome (MS). Neurological deficit was assessed with NIHSS and SSS, laboratory panel included primary characteristics of hemorheology and hemostasis: platelet aggregation, beta-thromboglobulin, platelet factor 4, Von Willebrand factor, RBC aggregation and deformability. We found that disturbances of carbohydrate metabolism in patients with diabetes and MS affect all major pathways of hemorheology and hemostasis and lead to dysfunction of platelets, RBCs and endothelium. These changes along with the others metabolic abnormalities make an impact on clinical course of stroke and may significantly affect outcome due to the prolonged recovery and high rate of residual deficit.