Abstract
Hemophilia is an X-linked recessive inherited disorder. The main clinical manifestation is hemorrhage, the extent of which depends on the level of coagulation factor VIII or IX in the plasma, generally secondary to deep trauma, such as joints, muscles and the central nervous system. Objective: To present a clear and practical bibliographic review of hemophilia, addressing general aspects of pathophysiology, diagnosis and management, as well as new therapeutic alternatives under development for its treatment. Methods: The databases PubMed, Scopus, ScienceDirect and Scielo were searched using key words in Spanish and English. Twenty articles were selected as a basis for the construction of this review, but 5 were not used because their publication date was more than 5 years old. Results: A literature review was developed that included basic and practical concepts of hemophilia treatment methods and approaches. Conclusions: Hemophilia is a life-threatening disease that affects patients' quality of life, so developing an appropriate diagnosis and treatment is a challenge.
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