Abstract
In medieval legend, the Holy Grail was the cup used by Jesus at the Last Supper. Allegedly brought to Britain by Joseph of Arimathea, it became the quest of many knights. In modern times, “holy grail” has been used to denote a greatly desired object or outcome whose pursuit borders on a sacred quest. Gene therapy for hemophilia has been one of our field's holy grails for more than two decades, and this much-sought-after application of gene transfer technology has finally been achieved in patients, as reported at the annual meeting of the American Society of Hematology (ASH) in December 2010.
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