Hemophilia B (factor IX deficiency) in a Labrador retriever dog

Abstract

Abstract A 3-month-old intact male, Labrador retriever was presented with the history of coagulopathy and anemia. The results of initial screening tests of the hemostatic system yielded a tentative diagnosis of hemophilia. Activated partial thromboplastin time (APTT) was distinctly prolonged (106 seconds) and prothrombin time (PT) was not detected due to markedly prolonged test time. Whole blood trans-fusions (20 me l/kg body weight) were carried out prior to assays of coagulation factor. After trans-fusion, the patient recovered well and hemorrhage ceased. Blood samples were assessed for coagu-lation factor activity. The patient showed markedly low factor IX coagulation activity (5%, reference range: 7∼140%) and was diagnosed with hemophilia B. After recovery, the patient was discharged from the hospital. However, 4 months later the patient was re-hospitalized for recurrence of the initial symptoms. The owner did not want to pursue further treatment and the patient died of respiratory dis-tress two days later.