Abstract
Since the blood of group O contains no agglutinogens, Ottenberg 1 in 1911 proposed the use of individuals of this group as universal donors. It was thought that the agglutinins α and β would be sufficiently diluted in the recipient's serum as to be ineffectual. The practice of transfusing group O blood into individuals of other groups has become fairly common, although many writers have warned against it. Copher 2 stated that the use of the universal donor was dangerous. Levine and Mabee 3 studied the blood of one individual belonging to group O whose serum agglutinated the corpuscles of group A in a dilution of 1:120. Freeman and Whitehouse 4 found a group O blood the α agglutinin of which was active in a dilution of 1:80. The β agglutinin reacted in a dilution of 1:48. Neither of these bloods was actually used for transfusions. Thomsen 5
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