Abstract
During the last 25 years there has been a vast increase in the understanding of re actions between red cell antigens and anti bodies, and this increased knowledge has lessened the hazards of transfusion by im provement of pre-transfusion tests. These include tests in saline solution and high protein media, as well as enzyme and anti globulin methods. Despite such refinements, experiences have been reported in which transfusion of seemingly compatible blood has resulted in hemolysis of the donor cells. Lou tit and associates 8 observed incompati bility without demonstrable antibodies in 1943. Severe hemolytic transfusion reaction after the administration of apparently compatible blood was observed in 2 cases presented by Fudenberg and Allen. 2 Osborn and Bailey 10 described a case of hemolytic transfusion reaction without demonstrable incompatibility with saline solution, al bumin, or antiglobulin technics. Sensitiza tion in this case was believed to have oc curred 46 years previously. Other examples may be cited. 3 - 6 ' 7 - 9 - • 12
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