Hemoglobin levels as a surrogate marker of sarcopenia in patients with liver cirrhosis.

Abstract

This study aimed to elucidate a surrogate marker of sarcopenia in patients with liver cirrhosis (LC). A total of 424 patients were assessed for handgrip strength (HGS) and skeletal muscle index (SMI). They were divided into two groups: sarcopenia (Group S; n = 80) and nonsarcopenia (Group NS; n = 344). Group S showed significantly lower HGS, SMI, and hemoglobin (Hb) levels in males and females; and lower serum levels of albumin, cholinesterase, and zinc (all p < 0.001), along with significantly higher serum levels of procollagen Type III-N-peptide and type IV collagen 7S-domain (p < 0.001 and p < 0.0017) than Group NS. The risk factors for sarcopenia were age ≥ 65 years, female, Child-Pugh class C, and Hb levels < 10.9 g/dL in females and < 12.4 g/dL in males (p = 0.012, p < 0.001, p = 0.031 p < 0.001). Significant positive correlations were found between the Hb level and the SMI and HGS (r = 0.4 p < 0.001, r = 0.4 p < 0.001). Sarcopenia, low HGS, and low SMI were significantly associated with overall survival in patients with LC (all p < 0.001). The predictive accuracy of Hb levels for predicting sarcopenia was significantly higher than that for predicting SMI and tended to be higher than that for predicting HGS (p = 0.014 and p = 0.059, respectively). Hb levels are predictive of sarcopenia in patients with LC and warrants further investigation as a biomarker for sarcopenia in LC. This article is protected by copyright. All rights reserved.