Abstract
Hb G Hsi-Tsou was found in Taiwan, in 1964, in two Chinese sisters who were born in Hopei Province. Structure analyses now have shown that the anomaly in this variant is at the β-79 or βEF3 position where a glycyl group replaces the aspartyl group normally present at that location. Another hemoglobin variant found in Chinese subjects, Hb G Taichung, previously has been reported to have the structure change Asp → His at the corresponding location in the α chain, Position αEF3 or α-74. In the index case separations of the hemoglobin fractions by chromatography with DEAE-Sephadex column revealed that the relative amounts of Hbs A 0 and G Hsi-Tsou were 54 and 46%, respectively. Presence of HbG Hsi-Tsou in the heterozygote apparently causes no anemia.
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