Abstract
BackgroundWe previously reported on the positive association of hemoglobin with hypertension and atherosclerosis. On the other hand, hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage. However, no studies have reported on a correlation between hemoglobin and HGF accounting for hypertension status.MethodsA cross-sectional study of 1108 subjects (392 men and 716 women, 40–93 years old) who were undergoing a general checkup in 2014 was conducted.ResultsMultiple linear regression analysis adjustment for known cardiovascular risk factors showed no significant correlation between hemoglobin and HGF in non-hypertensive subjects, but a significant positive correlation in hypertensive subjects; β (parameter estimate) = 0.3 (p = 0.975) for non-hypertensive men, β = 0.4 (p = 0.925) for non-hypertensive women, β = 32.7 (p < 0.001) for hypertensive men, and β = 18.7 (p = 0.002) for hypertensive women.ConclusionWe found a significant positive correlation between hemoglobin and HGF among hypertensive men and women. Like HGF, hemoglobin may be a useful indicator to evaluate hypertension-induced vascular damage. Since hemoglobin can easily be measured, these results support hemoglobin as an efficient tool to evaluate vascular damage induced by hypertension in daily medical practice.
Highlights
We previously reported on the positive association of hemoglobin with hypertension and atherosclerosis
Hemoglobin is an measured parameter; if it can substitute for Hepatocyte growth factor (HGF) as a possible biochemical index of vascular damage due to hypertension [4, 10,11,12,13,14], it could serve as an efficient tool for blood pressure control in daily medical practice
We hypothesized that non-hypertensive men and women would show no significant correlation between hemoglobin and HGF, whereas a significant correlation would be found in subjects with hypertension
Summary
We previously reported on the positive association of hemoglobin with hypertension and atherosclerosis. Hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage. Other studies have reported HGF as a possible biochemical index of vascular damage due to hypertension [4, 10,11,12,13,14]. Another study reported a significant correlation between increased HGF concentration and carotid atherosclerosis [15]. Hemoglobin is an measured parameter; if it can substitute for HGF as a possible biochemical index of vascular damage due to hypertension [4, 10,11,12,13,14], it could serve as an efficient tool for blood pressure control in daily medical practice. We hypothesized that non-hypertensive men and women would show no significant correlation between hemoglobin and HGF, whereas a significant correlation would be found in subjects with hypertension
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