Hemoglobin and hematocrit levels are positively associated with blood pressure in children and adolescents 10 to 18\xa0years old

Hwal Rim Jeong,Young Suk Shim,Jin Soon Hwang,Hae Sang Lee

doi:10.1038/s41598-021-98472-0

Hwal Rim Jeong, Young Suk Shim + Show 2 more

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https://doi.org/10.1038/s41598-021-98472-0

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Abstract

To investigate the associations between hemoglobin (Hb) concentration and hematocrit (Hct), and blood pressure (BP) in children and adolescents. The study population consisted of 7950 subjects total (4229 boys and 3721 girls) aged 10–18 years who participated in the Korea National Health and Nutrition Examination Surveys conducted between 2007 and 2017. The prevalence of hypertension was 19.19% (21.51% for boys and 16.5% for girls) among the study population, and the prevalence of obesity was 9.59% (10.5% for boys and 8.6% for girls). Hb count and Hct tended to increase with the degree of obesity and BP elevation. Systolic BP (SBP) and diastolic BP (DBP) positively correlated with Hb count and Hct in both sexes. Following multiple linear regression analysis, Hb count and Hct presented a positive association with SBP and DBP after adjusting for age, BMI SDS, alcohol consumption, smoking status, physical activity, rural residence, household income, diagnosis of T2DM, hypertension, and dyslipidemia. Hb count and Hct were positively associated with SBP and DBP in children and adolescents 10–18 years old.

Highlights

To investigate the associations between hemoglobin (Hb) concentration and hematocrit (Hct), and blood pressure (BP) in children and adolescents
Systolic BP (SBP), diastolic BP (DBP), and serum glucose concentrations were higher for boys, and concentrations of TC, TG, HDL-C, and LDL-C were higher for girls
Mean Hb count and Hct tended to increase among BMI groups, but there was no statistical significance in girls

Summary

Introduction

To investigate the associations between hemoglobin (Hb) concentration and hematocrit (Hct), and blood pressure (BP) in children and adolescents. Hb count and Hct were positively associated with SBP and DBP in children and adolescents 10–18 years old. In children younger than 13 years old, elevated blood pressure (BP) is defined as BP in the 90th percentile or higher considering age, height, and sex, and HTN is defined as BP in the 95th percentile or h igher[10]. Only a limited number of large-population studies have shown an association between Hb concentration and BP20–23. The current study investigated the prevalence of HTN and obesity and the associations between Hb count and hematocrit (Hct), and BP in children and adolescents using data from the 2007–2017 Korea National Health and Nutrition Examination Survey (KNHANES)

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