Hemofili A Hastalarındaki Diz Artropatisi ve Bilateral Total Diz Artroplastisi Oranı

Abstract

Objective: This epidemiological study was co nducted in the joint haematology- orthopaedics clinic of a university hospital. The aim was to analyse the data in terms of age and radiolo gy of patients with moder ate or severe haemophilia A and knee involvement. Materials and Method: This was a retrospective stu dy 49 patients with knee problems out of 130 haemophilia A and musc u loskeletal problems . Kellgren-Lawrence (KL) classification was used for radiological assessments of osteoarthritis degree. Results: KL degree was 3 or 4 for most patients (27/39, 69.23%) in the group. There was statistically a meaningful correlation between KL degree and patients’ age (Spearman’s: r s = 0.512, p = 0.001). There were 7 patients with KL degree 4 at the age of 50 or younger (14.29%). 25 patients in 49 (51.0 2%) had total knee arthroplasty(TKA) and 10(40%) of those was bilateral . Mea n age for bilateral TKA (56.3 5 ) was higher than unilateral(49.87 ). There was a statistically mea ningful correlation between patient age and the patients with TKA (Spearman’s : r s = 0.338, p = 0.017 ). There were 2 revision surgeries out of 35 TKA (5.7 1 %). Most of the patients had prophyl actic factor treatment (43, 87.75 %). Conclusion: Our study signify the high ratio of bilateral knee replacements in haemophilia A patients and how early age they progressed to KL stage 4 comparing to normal population. These results show the importance of patient care in this group of patients, close follow-up and prophylactic treatment. They should be managed in experienced centres by an experience team to decrease the risks and complications.