HEMODYNAMICS OF ENDOTOXIN SHOCK IN NEWBORN PUPPIES

Abstract

Reports on neonatal hemodynamics in Endotoxin shock(ETX) are sparse. This study reports 58 newborn mongrel puppies, 260-800 grams in whom cardiac output(CO), mean arterial pressure(MAP), systemic vascular resistance(SVR), and minute work(MW), were measured q10 min. in controls (N=30) and 2 experimental groups receiving Ecoli(ETX) at a dosage of 1.5 mg/kg(group A=15), and 10 mg/kg(group B=13). RESULTS: MAP: fell below controls at 50 min. in group B, and at 70 min. in group A with parallel fall thereafter. CO: decreased immediately to 60% of control in both groups, and continued to decrease throughout the experiment, with gradual convergence of both groups at 120 min. SVR: rose to 200% in both groups A and B, and remained elevated throughout. MW: fell in both groups to 55% of control. SUMMARY: Newborn puppies respond to ETX with ↓ CO, ↓ MW, ↑ SVR, and late ↓ MAP, in contrast to adults subjects. Quantifications of interventions are now possible with this model.