Abstract
The progression of a cerebral aneurysm involves degenerative arterial wall remodeling. Various hemodynamic parameters are suspected to be major mechanical factors related to the genesis and progression of vascular diseases. Flow alterations caused by the insertion of coils and stents for interventional aneurysm treatment may affect the aneurysm embolization process. Therefore, knowledge of hemodynamic parameters may provide physicians with an advanced understanding of aneurysm progression and rupture, as well as the effectiveness of endovascular treatments. Progress in medical imaging and information technology has enabled the prediction of flow fields in the patient-specific blood vessels using computational analysis. In this paper, recent computational hemodynamic studies on cerebral aneurysm initiation, progress, and rupture are reviewed. State-of-the-art computational aneurysmal flow analyses after coiling and stenting are also summarized. We expect the computational analysis of hemodynamics in cerebral aneurysms to provide valuable information for planning and follow-up decisions for treatment.
Highlights
Aneurysm is a vascular disease characterized by local dilatation of arterial walls
We review recent computational hemodynamic studies on cerebral aneurysm initiation, growth, and rupture, as well as computational studies on aneurysmal flow alterations induced by interventional treatment with coils and stents
Mantha et al [37] constructed computational models of carotid artery lateral aneurysms based on the patient 3D angiography data, and performed computational fluid dynamic (CFD) analysis was performed for the parent vessel prior to aneurysm formation
Summary
Aneurysm is a vascular disease characterized by local dilatation of arterial walls. Aneurysms are frequently observed in the intracranial space and exhibit fusiform or saccular shapes. Recent progress in medical imaging technology and improvements in computer equipment have enabled computational fluid dynamic (CFD) analysis to predict the hemodynamics of aneurysms with increased accuracy and reliability. Patient-specific CFD analysis involves imaging data process, mesh construction, computational calculations, and postprocessing. The whole pipeline from medical images to flow calculations has been developed in order to eliminate manual intervention and editing of data processing. If the hemodynamic factors affecting aneurysm etiology are elucidated, CFD analysis based on the patient-specific images data will provide a better understanding and diagnosis of aneurysm progress and rupture. We review recent computational hemodynamic studies on cerebral aneurysm initiation, growth, and rupture, as well as computational studies on aneurysmal flow alterations induced by interventional treatment with coils and stents
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