Hemodynamic ,thyroid and immunomodulater effects of cannabinoid in rats.

Abstract

The aims of the present study are to investigate the cannabinoid effects on serum
 monocyte chemoattractant protein-1 (MCP-1), Troponin-1 ,liver and renal test
 parameters. The experimental rats were divided into three groups, the first group served
 as a control, and the animals were injected with normal saline. In the second group,
 animals were injected with cannabis (5 mg/kg, intraperitonial), while in the third group
 animals were injected with cannabis (10 mg/kg). After the course of the experiment,
 systolic blood pressure (SBP) tended to reduce significantly in the second dose of
 cannabis administered rats. Serum nitric oxide (NO) level slightly increased in dose
 dependent manner but it did not reach the level of significance. Serum level of
 malondialdehyde (MDA), troponin-T, MCP-1 and serum total bilirubin were
 significantly increased in the second dose of cannabis administration as compared to
 control rats. Neither triiodothyronin (T3) nor tetraiodothyronin (T4) hormones had
 statistically changed in cannabis group comparing with the control rats. Furthermore,
 serum uric acid reduced in cannabis group as compared with control. In conclusions, for
 the first time, our findings suggested that cannabis could affect immune system through
 MCP-1 elevation. As well as, cannabis may affect cardiac and liver functions via
 increasing troponin-T and bilirubin levels.