Abstract
Abstract
 Objective: To identify the differences of hemodynamic profile and morphometric changes of maternal heart in normotensive and severe preeclampsia (early-onset and late-onset) pregnant women.
 Method: Cross-sectional study on consecutively selected 34 pregnant women which divided into three groups: normotensive group (n = 12), early-onset group (n = 11), and the late-onset group (n = 11). Conducted in the ER and inpatient care unit of Obstetrics and Gynecology Department, Faculty of Medicine Sriwijaya University / Dr. Moh. Hoesin Hospital Palembang, from April 2015 - June 2015.
 Results: There are significant differences in CO and SVR among three groups. In early onset groups, CO values are lower (3.4 + 0:27, p <0.001) with higher SVR (3100.2 + 261.3, p <0.001) compared the other two groups. There is increased of SVR in preeclamptic group compared to control, where SVR is higher in the early onset compared to late-onset group (3100.2 + 261.3 vs 2217.1 + 407.8, p <0.001), as well as differences between groups in cardiac index variables, except in the early onset group and controls (p = 0.045). In blood pressure and MAP variable, we only notice difference between the early onset group and control (p <0.001) as well as late-onset group and controls (p <0.001). There are significant differences in LVMi, LVID and LVPWT among three groups, in which the control group was lower than the other two groups (p <0.001; p = 0.049; p = 0.009), but similar in early and late-onset groups (98.7 (86.5-203) vs 132 (77.7-17.6); 4.7 (0.4) vs 4.8 (0.5); 1.1 (0.7-1.3) vs. 1.1 (0.8-1.6)). While RWT relatively similar among the three study groups (p = 0.264). A post hoc analysis showed no differences in maternal heart morphometry in early onset and late-onset group (p> 0.05).
 Conclusions: In severe preeclampsia there are changes in hemodynamic, ventricular morphometry, and left ventricular function. But the changes that occurred seems to be more evident in the early onset preeclampsia group of compared than late-onset preeclampsia.
 Keywords: Normotensive, early onset PEB, PEB late-onset, hemodynamic profile, cardiac morphometry.
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