Hemodynamic of Post-Dynamic Submaximal Exercise in Obese Women with and without Type 2 Diabetes

Abstract

1459 PURPOSE: Post-exercise hypotension (PEH) is the decrease in resting systolic blood pressure (SBP) after an acute bout of exercise. PEH has been attributed to decreases in vascular resistance and cardiac output in hypertensives but hemodynamic responses may differ in other clinical populations. To evaluate the hemodynamic contributors to the hypotensive effect of a single bout of dynamic exercise in obese women (30.1–43.4 kg/m2, 45–59 years) with (n = 8) and without (n = 9) type 2 diabetes (T2D). METHODS: We evaluated SBP, total peripheral resistance (TPR), stroke volume (SV), heart rate (HR), and cardiac output at pre-exercise and at 10, 20, and 30 min after 20 min of treadmill exercise at 65% of VO2 max. Hemodynamic variables were measured using beat-to-beat finger plethysmography (Portapres) in the supine position. Data were analyzed using an ANOVA with repeated measures (pre-exercise, 10, 20, and 30 min post-exercise). RESULTS: SBP was significantly (p<.05) reduced from pre-exercise at 10–30 min into recovery in the obese group but not in the T2D group. SBP changes from pre-exercise to 30 min post-exercise were significantly (p<.05) greater in the obese group (− 9 ± 10 mm Hg) compared to the T2D group (3 ± 11 mm Hg). Both groups demonstrated a similar change in TPR during recovery with a reduction at 10 min followed by a significant (p<.05) increase at 30 min post-exercise. SV was significantly (p<.05) reduced from pre-exercise at 10–30 min post-exercise in both groups without significance between groups. HR was significantly (p<.05) increased from pre-exercise at 10 and 20 min but not at 30 min post-exercise in both groups. Cardiac output changed significantly (p<.05) from pre-exercise values to the lowest level at 30 min post-exercise in the obese (− 0.7 ± 0.7 L/min) and T2D (− 0.5 ± 0.9 L/min) (p = .09 for group × condition interaction). CONCLUSIONS: These findings indicate that PEH during 30 min after submaximal exercise is observed in obese women without T2D but not in obese women with T2D. PEH in obese women without T2D is mediated primarily by a reduction in cardiac output due to a large decrease in SV. The higher SBP at 30 min post-exercise in T2D women was primarily due to lower decrease in cardiac output, since the increase in TPR was similar in both groups. Sponsored by NY State Diabetes Bridge Grant