Abstract
Thermal injuries are wide spread among home pets and are represented as a recent problem of veterinary medicine because of the lack of anti-burn drugs adapted for use in veterinary medicine. In this regard, the aim of our work is to certify the vulnerary spray “Acerbin” for medical purposes in the treatment of thermal injuries of animals and to evaluate its therapeutic potency according to the dynamics of healing burn injuries and recovery of the blood cell composition. The research was carried out on 60 laboratory white mice. Thermal injuries of the skin integument on the dorsal surface of the croup were simulated; the “Acerbin” spray was further applied. To achieve the aim, the blood samples and planimetric measured tests of the area of burn defects were taken on the 3rd, 5th, 7th, 10th and 14th day of treatment. The samples were analyzed by the quantitative content of erythrocytes, thrombocytes, leucocytes and cHb (blood hemoglobin concentration) using an automatic hematological analyzer “Abacus vet 10”. Planimetric indicators of the area of burns were subjected to mathematical processing with the calculation of the rate of epithelization of the burn injury. The obtained hematological and planimetric digital indicators were processed by statistical methods of analysis, compared and then interpreted.
Highlights
Thermal injury is the skin integument and deep-lying tissues damage, appeared as a result of high temperatures exposure [1]
It can be compared to the values of 6.08±0.21 G/mcl (p≤0.05), thrombocytes - by 37.58% (297.00±26.48 T/mcl) (p≤0.05) and a sharp increase of the leucocytes quantitative content by 53.11% (7.38±1.20 T /mcl) (p≤0.05) relative to pre-therapeutic indicators in a sign of burnt area reduction by the 3rd day
The research showed that the usage of the vulnerary spray “Acerbin” in the treatment of thermal injuries of animals has a positive influence on the dynamics of reducing the burns area
Summary
Thermal injury is the skin integument and deep-lying tissues damage, appeared as a result of high temperatures exposure [1]. The world pharmaceutical market offers a wide choice of drugs, but most of them are not adapted to veterinary usage This fact complicates the medical activities of vets faced with the problem of the necessity of burning injury treatment for animals [3]. In this regard, the development of new anti-burn veterinary drugs that can effectively reduce the healing time of burn defects is necessary. The development of new anti-burn veterinary drugs that can effectively reduce the healing time of burn defects is necessary Such drugs can normalize hemodynamic parameters that significantly affect the relief of polymorphic pathology of burn injury animals [4]. That is why the aim of our work is to certify the vulnerary spray “Acerbin” for medical purposes in the treatment of thermal injuries of animals and to evaluate its therapeutic potency according to the dynamics of healing of burn injuries [5]
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