Abstract
Abstract In 16 males with ischemic heart disease the acute hemodynamic effects of a new β‐blocker, oxprenolol, have been studied during rest and exercise by right heart catheterization technique. The myocardial oxygen‐saving effect of oxprenolol was demonstrated by a significant reduction of heart rate during exercise and a widened arterio‐venous oxygen difference. Addition of nitroglycerin rapidly and markedly reduced myocardial oxygen demand by reducing the left ventricular filling pressure and the mean systemic arterial pressure. Oxprenolol and nitroglycerin can be combined without any untoward effects and without loss of efficiency of either drug. However, no evidence of synergism between the two drugs was found in this study.
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