Abstract
Marked elevations in cardiac output and reductions in systemic vascular resistance are well-documented features of steady-state sickle cell disease 1–4; however, measurements of central hemodynamic changes during acute vaso-occlusive crises have not been reported. Doppler ultrasound measurement of ascending aortic blood flow provides a convenient and reliable means of noninvasive monitoring of changes in cardiac output. 5,6 We used Doppler ultrasound to study hemodynamic changes in patients with acute vaso-occlusive crises during their hospital admission. We then compared these with values obtained during the noncrisis steady-state, and also with those of an age-matched group of normal subjects.
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