HEMODYNAMIC ANDCYTOLOGIC CHANGESINPROSTATE GLANDCAUSED BY CHRONIC HEPATITIS

Abstract

The aim: Is to determine the features of hemodynamics and the character of structural and functional changes in the prostate gland in middle-aged infertile males in the conditions of chronic hepatitis. Materials and methods: We studied the features of hemodynamics and structural and functional state of the prostate gland in middle-aged males who had suffered from chronic hepatitis with the help of ultrasound scanning, Color-Doppler sonography, and histology, morphology, and statistics. Results: It was detected that in 3-5 years after chronic viral hepatitis in middle-aged males (the first period), the volume of the prostate gland increases to (27.1±1.2) cm3, and its mass to (28.0±1.7) g compared to the control. Blood flow rates in the prostate gland: arterial blood flow velocity, blood flow diastolic velocity, volumetric blood flow are significantly lower than the control ones. Glandular zone surface decreases to 53% and connective tissue increases to 43%. Epithelium in the secretory area of the gland is compressed. Conclusions: 1.According to the data of ultrasound diagnostics and Color-Doppler sonography, the volume of the prostate gland increases to (27.1±1.8) cm3 and its mass to (28.0±1.7) g at chronic viral hepatitis, compared to the control (21.3±1.5) cm3 and (24.7±1.3) g (р<0.05). Atrophic changes in the prostate gland are manifested with the decreased height of the columnar epithelium of the gland and overgrowth of connective tissue in the stroma of the organ. 2.Angioechometric indices of arterial blood circulation in central and peripheral zone of the prostate decreases to (7.26±0.46) cm/sec and (7.80±0.32) cm/sec respectively compared to the control (18.30±3.10) cm/sec and (17.70±2.90) cm/sec. Venous blood flow rates decrease to (2.45±0.21) cm/sec and (2.60±0.16) cm/sec compared to (5.54±0.8) cm/sec and (5.36±0.03) cm/sec (р<0.05).