Abstract
Simulation of heart and particularly heart valves is amongst the most common and fundamental methods in diagnosis and treatment of heart disorders. Replacement of natural valves with prosthetic valves is a prevalent treatment to valvular damages. The idea of using tissue engineering heart valves is in progress in developing countries. This is because of their unique biocompatibility and biodegradability according to special characteristics and geometries of every single patient’s heart. By considering and changing specific parameters for optimization of valve design, one can obtain the most favorable dimensions of the scaffold. So far, there are various studies which have been focused on leaflet stress distribution and deformation, but considering the blood in these studies have been less taken into account. Excellence of considering fluid structure interaction is to provide real physiological condition for heart valve simulation. Simulation of bioprosthetic heart valve with 19[Formula: see text]mm diameter for various geometries of leaflets was performed. Hemodynamic parameters such as mean velocity, flow rate, transvalvular pressure drop, effective orifice area, wall shear stresses, and structural parameters like Von Mises were investigated. Results indicated that leaflet with 12[Formula: see text]mm height among other geometries is the best case for hemodynamic parameters and Von Mises stress.
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