Abstract
It is well established that cerebral activation is accompanied by an increase of cerebral blood flow (CBF) and glucose metabolism which exceeds a smaller increase in oxygen consumption. Thus, cerebral activation is accompanied by an uncoupling of the normal relations between blood flow and oxygen metabolism as well as of the ratio between oxygen and glucose consumption. The present communication discusses the physiological relevance of these changes and whether or not they are necessary in order to maintain an adequate brain function. Experimental studies in rat demonstrated that the uncoupling of the ratio between oxygen and glucose consumption during activation is reset by β-adrenergic blockade with Propranolol.
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