Abstract
Changes of blood pressure (BP), creatinine clearance (Ccreat), plasma renin activity (PRA), plasma aldosterone concentration (PAC) and urinary excretion of adrenaline and noradrenaline (uAD, uNAD) were studied in 5 normal subjects following i. v. infusion of 1-sarcosine, 8-isoleucine angiotensin II (sar1, ile8-A II) and angiotensin II (A II). The effects of variable sodium balance on these changes were studied as well. Sar1, ile8-A II demonstrated variable agonistic activities at 4 sites of A II action, i.e., Ccreat, PRA and PAC. There seemed to be a reciprocal relation between agonistic and antagonistic activities (latter being evaluated by antagonism against A II-induced changes of BP, Ccreat, PRA and PAC) of sar1, ile8-A II at each of sites, which would rather suggest similarity than heterogeneity of A II receptors at these sites. It was disclosed that agonistis activities on BP, PRA and PAC were dependent on sodium balance, i.e., most agonistic during sodium repletion and least active during sodium depletion. The implications of these findings were discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
