Hemodiafiltration and Oxidative Stress in Dialysis Patients

Abstract

on oxidative stress’, is echoed in the conclusions of Gonzalez-Diez et al.: ‘HFR induces less oxidative stress than HD-PS’. Both papers thus suggest that, as stated in the abstract to our paper: ‘Given, the strong relationship between oxidative stress and inflammation and their impact on the long-term cardiovascular complications in end-stage renal disease patients, HFR might have a more beneficial impact in reducing the risk of atherosclerotic cardiovascular disease in dialysis patients’. That two independent investigations reach the same conclusions can only strengthen the case for the HFR-based approach to oxidative stress-related longterm complication of hemodialysis and will hopefully lead to improved care for dialysis patients, which after all is everyone’s ultimate goal. We have read with interest the report by Gonzalez-Diez et al. entitled ‘Effect of a hemodiafiltration session with on-line regeneration of the ultrafiltrate on oxidative stress: Comparative study with conventional hemodialysis with polysulfone’ recently published in Blood Purification [1] . We are puzzled by the lack of any acknowledgement in this report of our work that was published in May of 2007 [2] . This oversight is particularly odd as not only the title of Gonzalez-Diez et al.’s report is almost exactly the same as ours, but both the basic premise and experimental approaches of Gonzalez-Diez et al.’s paper are virtually identical to the paper we published. Moreover, our conclusion published in 2007 that this approach to dialysis reduces oxidative load, i.e. ‘The results of our study indicate that HFR treatment, compared with standard dialysis, has a lower impact Published online: March 27, 2009