Abstract
Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown that low CNF concentration (about 0.5%) leads to an increase in fiber tensile strength due to the additional orientation of chitosan macromolecules. At the same time, with an increase in the content of CNF, the stability of the mechanical properties of composite fibers in a humid medium increases. All chitosan fibers, except 0.5% CNF, showed good hemocompatibility, even on prolonged contact with human blood. The addition of chitin nanofibers leads to decrease in hemoglobin molecules sorption due to the decline in optical density at wavelengths of 414 nm and 540 nm. Nevertheless, the hemolysis of fibers was comparable or even lesser that carbon hemosorbent, which is actively used in clinical practice.
Highlights
Most implantable medical devices involve contact with human blood [1]
The purpose of this work is to develop composite fibers based on chitosan and chitin nanofibrils with subsequent research on its physical and mechanical properties, along with hemocompatibility
Further concentration of chitin nanofibrils (CNF) causes the formation of a cluster structure and, respectively, the decrease of mechanical characteristics of the composite fibers
Summary
Most implantable medical devices involve contact with human blood [1] These include prosthetic heart valves and blood vessels, filters, stents, shunts, and many others. In connection with the increasing volume of this group, the ISO 10993-4 was developed [2] It considers the various applications of products that require compliance with hemocompatibility, and suspends various types of tests. They are included in the following categories: study of thrombosis, coagulation, hematological indications and hemolysis, the behavior of platelets, and the complement system. Changes in the optical density of blood plasma over a long time (60 min) of contact between sorbent and human blood were investigated
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