Abstract

Surface modification of cellulose hemodidlysis membrane with phospholipid polymer was investigated to reduce protein adsorption, platelet adhesion and complement activation. The mechanical properties and permeation for solutes were did not change even after the modification. Both protein adsorption and complement activation after contact with plasma were significantly suppressed by the modification compared with these of the original membrane. Moreover, platelet adhesion was completely inhibited on the phospholipid polymer-modified cellulose membrane.

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