Hemocoagulation Disorders and Intoxication in Severe Acute Post-Manipulation Pancreatitis in the Experiment

Abstract

Introduction. Acute post-manipulation pancreatitis (APMP) is a frequent complication aſter interventions on the major duodenal papilla. The APMP incidence reaches 15 %, of which 5–10 % are severe. The goal of the research is to determine the possibility of correcting hemocoagulation disorders and reducing endogenous toxemia syndrome severity in APMP.Materials and methods. A comparative study was performed in 40 animals (nonlinear albino rats) with severe acute pancreatitis on APMP experimental model. L-17 compound from a new group of organic compounds substituted thiadiazines at a daily dose of 40 mg/kg was used.Results. The development of hemocoagulation disorders and severe toxemia in animals with an experimental model of APMP has been shown. The indicators of the severity of hemocoagulation disorders and toxemia were studied in experimental APMP against the background of the introduction of the compound L-17 from the group of substituted thiadiazines.Discussion. The course of APMP in the experiment is accompanied by the development of severe hemocoagulation disorders and severe toxemia. Effective indicators reflecting the severity of APLP are D-dimers (hemocoagulation) and albumin binding capacity (toxemia).Conclusion. The course of experimental severe APMP is accompanied by pronounced hemocoagulation disorders development involved in the pathogenesis and progression of multiple organ dysfunction, that is characterized by a high level of endogenous toxemia. The course of experimental APMP against the background of the introduction of the compound L-17 is marked by a decrease in the severity of hemocoagulation disorders and the level of endogenous toxemia.