Abstract
Researchers at University of Calgary and Alberta Children's Hospital, Canada; and University of Pennsylvania, Philadelphia studied brain resections from 3 male infants with hemimegalencephaly (HME) and refractory epilepsy.
Highlights
Coordination of neurology, critical care, and interventional radiology is recommended in management of ischemic stroke in children
Proteus syndrome is caused by a mutation in AKT1, and is classed as a genetic mosaicism
Refractory epilepsy is more associated with abnormalities like hippocampal sclerosis or malformations of cortical development than with variations of the hippocampal formation itself
Summary
A PubMed search of the literature uncovers several single case reports of the successful use of thrombolysis in the treatment of childhood stroke. Use of alteplase in childhood arterial ischaemic stroke. Clinical trials are needed to determine optimal dose of alteplase in childhood stroke. Researchers at University of Calgary and Alberta Children’s Hospital, Canada; and University of Pennsylvania, Philadelphia studied brain resections from 3 male infants with hemimegalencephaly (HME) and refractory epilepsy.
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