Hemifield-specific color perception deficits after unilateral V4α lesions

Abstract

Functional neuroimaging and patient studies demonstrated significant involvement of ventral area V4α, located in the anterior ventral pathway, in color vision. A low number of case studies reported lesions in close vicinity to this region leading to symptoms of hemiachromatopsia indicating hemifield-specific processing of color information. With the present study, we present the first group study investigating hemiachromatopsia after injury to anterior ventral brain areas. In lateral stimulus presentations with several color perception tasks, we observed symptoms of hemiachromatopsia, which were specific to patients with unilateral lesions to the ventral pathway. Particularly, we identified unilateral lesions to area V4α as an important contribution to color perception deficits under demanding viewing conditions. Our results suggest that color information processed along the anterior ventral path is hemifield-specific and that selective deficits in color perception cannot be fully compensated by the intact contralesional visual stream.