Abstract

Context: Hemifacial spasm (HFS) is characterized by continuous or intermittent spasmodic movements at the facial nerve motor territory.1,2,3 It mainly affects middle- aged adults and usually occurs by compression of the facial nerve by anomalous vascular loops of the anteroinferior and vertebral cerebellar artery.2,3,4,5 The arachnoid cyst at the cerebellopontine angle (CPA) is an rare cause of HFS, especially in children. Case report: A six-year-old female patient started presenting at 18 months HFS on the right side. She was initially treated with anticonvulsant without improvement. The patient came to our care at the age of six presenting 2-3 HFS per day and remissions lasting 3-4 weeks. Image exams reveled a CPA arachnoid cyst compressing the VII and VIII nerves complex. Surgical drainage of the cyst was performed as the treatment of choice. In postoperative period, the patient presented remission of HFS, and cranial tomography showed a decrease in cyst volume. In three months, there was remission of the signs without use of any medications. Conclusions: There was no report of arachnoid cyst in CPA as a cause of HFS in children. HFS occurs probably by chronic irritation, since birth, because of the contact of arachnoid cyst in the emergence of the VII and VIII nerves complex in the PCA. Therefore, treatment was chosen according to the cause of HFS. Movement disorder as a clinical manifestation of the cyst is rare, especially in pediatric population, and should be considered as one of the diagnostic hypotheses.

Highlights

  • Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack

  • The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells

  • Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible

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Summary

Introduction

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation

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