Abstract
Heme Oxygenase-1 as a Novel Metabolic Player
Highlights
The inducible form of Heme oxygenase (HO), heme oxygenase-1 (HO1), confers protection against oxidative stress conditions in vitro and in vivo [5]
Heme oxygenase (HO; EC 1:14.99.3, heme, hydrogen donor: oxygen oxidoreductase (α-methene hydroxylating, decyclizing)) catalyzes the rate limiting the step in the oxidative catabolism of heme to generate biliverdin-IXα, which is subsequently converted to bilirubin-IXα by cytosolic NAD(P)Hdependent biliverdin reductase [1]
We sought to invite papers that explore the novel aspects of the HO-1/carbon monoxide (CO) system with respect to the regulation of metabolic pathways
Summary
The inducible form of HO, heme oxygenase-1 (HO1), confers protection against oxidative stress conditions in vitro and in vivo [5]. It has become clear that the HO-1/CO system can potentially impact cellular metabolic pathways. We sought to invite papers that explore the novel aspects of the HO-1/CO system with respect to the regulation of metabolic pathways.
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