Abstract
Background and Aims : Endothelial cells (ECs) have a crucial role in reendothelialization for repairing denuded arteries. Heme oxygenase-1 (HO-1) is a stress response protein that degrades prooxidant heme and generates molecules with antioxidative and anti-inflammatory properties. Given that redox status is critical in stem cell differentiation, our aims are to investigate the effects of HO-1 induction on human pluripotent stem cells (hPSCs) differentiation toward ECs and reendothelialization after arterial injury.
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