Hematoporphyrin- mediated focused ultrasound sonodynamic therapy combined with catheter- based rhenium-186 brachytherapy after B- mode ultrasound- guided balloon angioplasty of occluded artery

Abstract

Background and Aims : Three mechanisms are responsible for the development of restenosis: elastic recoil, intimal hyperplasia and late vascular constriction, all grouped under the catch phrase “negative remodeling”. Neointimal hyperplasia is usually defined in an artery as thickening of the intimal layer after an injury such as balloon angioplasty methods. The aim of this study was to evaluate the effect of combined ultrasound sonodynamic therapy and catheter- based 186Re-mediated beta radiation (β-) brachytherapy on restenosis reduction after balloon angioplasty.