Hematopoietic Progenitor Kinase 1 Inhibitors

Abstract

Cancer, a general name for wide range of diseases that have the ability to make an impact on any parts of the human body and has been a fatal health issue that affects people around the world. Hematopoietic Progenitor Kinase 1 (HPK1), one member from the MAP4K family, is a kind of serine/threonine kinase. Destruction of HPK1 kinase raises the secretion of cytokine and T cell signaling, having positive impact on clearance of virus, and inhibition of tumor growth. Thus, HPK1 has been seen as a promising target that can be used in drug development for immunotherapy of tumors. HPK1 has a pivotal role of inhibition on the signaling pathway of the T-cell receptor, it also inhibits the proliferation and differentiation of B cells, DC cells, and NK cells. In this paper, we aimed to supply a detailed overview of research including the introduction of HPK1, research process on HPK1 inhibitors and different methods of developing new kinase inhibitors.