Abstract
Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicine (TCM). Paeoniflorin (PF) and albiflorin (AF) are two major active constituents of P. lactiflora. In this paper, we aimed to investigate the hematopoietic effects of PF and AF on myelosuppression mice induced by radiotherapy and to explore the underlying mechanism. The finding indicated that PF and AF significantly increased the numbers of white blood cells (WBC) and reversed the atrophy of thymus. Furthermore, PF and AF increased the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) and reduced the levels of tumor necrosis factor-α (TNF-α) in serum and increased the level of colony-stimulating factor (G-CSF) in plasma. Lastly, PF and AF not only enhanced the mRNA levels of GM-CSF and G-CSF in the spleens, but also increased the protein levels of G-CSF and GM-CSF in bone marrow. Our results suggest that PF and AF may promote the recovery of bone marrow hemopoietic function in a myelosuppressed mouse model.
Highlights
The root of Paeonia lactiflora Pall is commonly used in China, Korea, and Japan
An active fraction from P. lactiflora containing paeoniflorin and albiflorin (CPA) showed ameliorative effects on myelosuppression induced by radio and chemotherapy [14]
Peripheral blood cell is derived from the proliferation and differentiation of hemopoietic stem cells and progenitor cells and bone marrow is in charge of the peripheral blood cells continuous replenishment [20]
Summary
The root of Paeonia lactiflora Pall (family Ranunculaceae) is commonly used in China, Korea, and Japan. There are a lot of major active constituents of P. lactiflora that have been identified, including paeoniflorin (PF), albiflorin (AF), oxypaeoniflorin, paeonilactinone, benzoyloxypaeoniflorin, and lactinolide [2]. Few pharmacological studies of AF were reported. We have found that PF and AF could suppress radiation and chemotherapy-induced myelosuppression [11,12,13]. An active fraction from P. lactiflora containing paeoniflorin and albiflorin (CPA) showed ameliorative effects on myelosuppression induced by radio and chemotherapy [14]. Jiang has proved the anti-inflammation effects of TGP on neutrophil cAMP-PDE activity in a rat arthritis model [6]
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