Abstract
The hematopoietic effects produced by administration of bone-marrow and spleen extracts,1by liver feeding,2and by intravenous injections of washed nuclei and sodium nucleate,3suggest that the results obtained may be due to a factor or to several factors which these substances possess in common.4A considerable amount of nuclear material is the most obvious common characteristic. We have therefore extracted nucleoproteins and nucleic acids from dog and beef livers, and have administered these, separately and in combination, into normal animals, with hematopoietic results very similar to those previously reported as the result of treatment with nuclei and sodium nucleate from fowl's blood. It should be stated that the nucleic acids obtained from livers were also in the form of sodium nucleate, and were prepared by the method of Kossel-Neumann. The nucleoproteins were prepared by the method of Hammarsten. In view of the results on normal
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