Abstract
When a piece of cellulose acetate membrane (CA membrane) is surgically inserted into the peritoneal cavity of a C3H/He mouse, a macrophage layer forms on the membrane. This was examined for its hematopoiesis-sustaining potentiality. After whole-body irradiation, membrane-bearing mice were injected i.p. with aliquots of isologous or homologous bone marrow cells. Myeloid colonies derived from donor bone marrow cells formed in the macrophage layer within several days of inoculation. The majority of the colonies was granuloid in nature; however, erythroid colonies were observed distinctly in some cases. Remarkable heterogeneity was noticed in the granuloid colonies. Colony-forming units on the CA membrane 2 days after bone marrow inoculation were shown. In conclusion, an artificial layer of peritoneal macrophages can in part perform the function of reticuloendothelial cells to sustain hemopoiesis. (auth)
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