HEMATOLOJİK MALİGNİTENİN MİYELOİD VEYA LENFOİD KÖKENİ SOLUNUM FONKSİYONU, KAS KUVVETİ, EGZERSİZ KAPASİTESİ VE YAŞAM KALİTESİNİ NASIL ETKİLER?

Abstract

Purpose: Although recipients’ muscle strength, exercise capacity and quality of life (QOL) may deteriorate during allogeneic hematopoietic stem cell transplantation (AHSCT), impacts on pulmonary function, muscle strength, exercise capacity, and QOL are still unknown in recipients based on immunophenotypes. Therefore, this study aimed to investigate retrospectively physical impairments and QOL between recipients with myeloid and lymphoid malignancies. Methods: Pulmonary function (FEV1, FVC, PEF, FEV1/FVC, and FEF25-75%), quadriceps and respiratory muscle strength, exercise capacity (incremental shuttle walk test, ISWT), and QOL of 25 recipients with myeloid (42.76±14.72 years) and 22 recipients with lymphoid (37.27±14.13 years) hematologic malignancies (>100 days post-AHSCT status) were analyzed retrospectively. Results: Age, gender, FEV1, FVC, PEF, quadriceps strength, QOL scores, and ISWT distance (lymphoid: 637.27±211.1 m, myeloid: 704±211.6 m, difference: 66.73 m) were similar between the groups (p>0.05). Lymphoid group’s FEV1/FVC and FEF25-75% values were statistically higher, and the percentage of ISWT distance (effect size d=0.97, power (1-b)=0.89), maximum inspiratory pressure (lymphoid: 106.64±23.99 cmH2O, myeloid: 121.88±24.4 cmH2O, difference: 15.24 cmH2O) and maximum expiratory pressure (lymphoid: 122.55±38.29 cmH2O, myeloid: 146.72±33.06 cmH2O, difference: 24.18 cmH2O) were significantly lower than the myeloid group (p<0.05). Conclusion: All recipients had common debilitating problems on exercise capacity, lower extremity strength, and QOL. However, recipients with lymphoid type disorder had more reduced respiratory muscle strength and exercise capacity. Small airway obstruction was more commonly observed respiratory dysfunction in recipients with myeloid type disorder. Modifying and adjusting contents of rehabilitation programs according to immunophenotype of hematologic malignancy should be considered in further study.