Abstract
Cannabis indica has widely reported traditional uses which include its use for stimulation and purification of platelets as well as body defense. Experiments were carried out to assess the impact of Cannabis indica leaf extract on hematological parameters of wistar rats. The results revealed that the extract (10–100 mg/kg p.o.) produced no significant change in the packed cell volume, haemoglobin, red blood cell count, total leucocyte count, monocyte, basophil, eosinophil, bleeding time and clotting time. Platelet count was significantly (P<0.05) increased at the dose of 100 mg/kg p.o. The results did not support the traditional use of the plant leaf for stimulation of blood production. It however showed improvement of non-specific immune responses involving phagocytosis and inflammation.
Highlights
Cannabis indica has widely reported traditional uses which include its use for stimulation and purification of platelets as well as body defense
Experiments were carried out to assess the impact of Cannabis indica leaf extract on hematological parameters of wistar rats
Acute Toxicity Studies: No overt toxicity signs or death were observed in rats and mice, 72 h post oral treatment with doses between 10 – 1000 mg/kg
Summary
Cannabis indica has widely reported traditional uses which include its use for stimulation and purification of platelets as well as body defense. Acute Toxicity Studies: The estimation of the median lethal dose (LD50) for the extract was done in Wistar rats orally [13]. Haematological methods which includes haemoglobin (Hb), packed cell volume (PCV), red blood cell count, total leucocyte count (WBC), differential leucocyte count, platelet count, bleeding time and clotting time were performed.
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