Abstract
BackgroundHematological reference intervals are used for medical decision tools for interpretation of numerical test results. Establishing of hematological interval among newborn babies is very important for the diagnosis of malignancy, anemia, bleeding disorders, and various infections. There are no locally established hematological reference intervals in Ethiopia. Thus, the aim of this study is to establish locally determined hematological reference interval among full-term newborns.MethodsA cross-sectional study was conducted from May 15 to July 30 2019 among 151 apparently healthy full-term newborns at Gondar University Hospital. About 3 ml of cord blood was obtained for analysis of Hematological parameters and determined by using Sysmex KX-21N (Sysmex Corporation Kobe, Japan) automated analyzer. Median, 2.5th and 97.5th percentile were computed.ResultMale to female ratio was almost equal. All hematological parameter had no statistically significant difference between males and females. The delivery types were not influenced its hematological values. The reference interval of white blood cells, red blood cells, platelets, hemoglobin, hematocrit, mean cell volume, and mean cell hemoglobin were (7.64–22.16) x109/l, (3.69–5.47)x1012/l, (132.74–413.4) x109/l, (13.32–19.64) g/dl and (39.42–58.06)%, (91.6-113.22)fl, and (30.48–38.02 pg), respectively.ConclusionsAll hematological reference intervals were established from full-term newborns at University of Gondar hospital was different from other studies in Nigeria, Iraq, Pakistan, Nepal, Saudi Arabia and Iran. Therefore, own determined reference value is very important for the clinicians to correctly diagnosis the patients at health facility levels.
Highlights
Umbilical cord blood (UCB) is the blood remaining after in the excluding of the placenta
All hematological reference intervals were established from full-term newborns at University of Gondar hospital was different from other studies in Nigeria, Iraq, Pakistan, Nepal, Saudi Arabia and Iran
The present study showed that mode of delivery had no influence of hematological parameters of the newborns which agrees to a study done by Fady M, et al reported that there was no significant difference in the mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), red cell distribution width (RDW), lymphocytes, and monocytes [18]
Summary
Background Umbilical cord blood (UCB) is the blood remaining after in the excluding of the placenta. It is considered as biological waste products. Establishing of hematological RI among newborns from UCB is very important for neonatologist for the diagnosis RBC disorders (like anemia and polycythemia), hematological malignancy, platelet disorders (like thrombosis and thrombocytopenia), autoimmune disease, certain genetic disorders problems, monitoring of the patients during in a therapeutic regimen and diagnosis of various bacterial infections [5,6,7]. Establishing of hematological interval among newborn babies is very important for the diagnosis of malignancy, anemia, bleeding disorders, and various infections. The aim of this study is to establish locally determined hematological reference interval among full-term newborns
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