Abstract
Background : Sickle cell disease has high prevalence in Central India, ranging from 9.4-22.2% in different communities. Chronic normocytic normochromic hemolytic anemia is the typical finding in Sickle Cell Anemia (SCA). The hematological profile worsens during the complications. Thus knowledge of the average values of hematological parameters will be of utility to the clinicians. Methods: A cross sectional study was carried out in the Department of Pathology at a Medical Institute in Central India over the period of one and half years. Two ml of venous blood sample was collected in dipotassium ethylene diamine tetraacetic acid (K2 EDTA) bulb for complete blood count from SCA patients in steady state and analysed by automated hematology cell counter. All statistical analysis was done after recording the complete data of hematological parameters on Excel worksheet. Result: This study had lower average values of total hemoglobin, Red Blood Cell (RBC) count and hematocrit. Age wise increase in hemoglobin and hematocrit was noted till fourth decade. Higher values of Red Cell Distribution Width (RDW) and Reticulocyte count; and normal values of RBC indices, Platelet count, Total Leukocyte Count and Granulocyte % was seen. Conclusion: The average value of hematological parameters suggest moderate normocytic normochromic anemia in SCA patients in steady state. A larger scale work is recommended in this region for a baseline hematological profile for guiding the clinicians in management of these patients DOI: 10.21276/APALM.1694
Highlights
Sickle cell disease (SCD), a group of related blood disorders which are caused by sickle hemoglobin (HbS), is clinically one of the most important hemoglobinopathies
A larger scale work is recommended in this region for a baseline hematological profile for guiding the clinicians in management of these patients
Sickle cell disease is prevalent in many parts of India including Central India, where the prevalence in different communities has ranged from 9.4-22.2%,[3] and the average frequency of SCD gene ranges between 22 to 44 %.[4]
Summary
Sickle cell disease (SCD), a group of related blood disorders which are caused by sickle hemoglobin (HbS), is clinically one of the most important hemoglobinopathies. It was first recognized as a hematological disorder more than 100 years ago and a molecular disease in 1949.[1] Sickle cell anemia (SCA i.e. SS), the homozygous state for HbS, is the most common and severe form. Knowledge of the average values of hematological parameters will be of utility to the clinicians
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