Hematological Profile of Adult Haemoglobin SS and SC Sickle Cell Patients in Stationary Phase: Evidences from National Teaching Hospital of Cotonou in Benin

Abstract

Background and Objective: Sickle cell disease is a major public health problem. The aim of this study was to determine the hematological parameters in the inter-critical period of adult sickle cell patients at the National Teaching Hospital CNHU-HKM of Cotonou.
 Materials and Methods: This is a descriptive study with analytical aims carried out from July 2021 to December 2021 in the hematology department of the National Teaching Hospital CNHU-HKM of Cotonou. An hemogram was performed using Sysmex XT 4000i on a total of 181 sickle cell patients including 119 Hb SS and 62 Hb SC. Data were analyzed using R software.
 Results: Patients studied had a mean age of 32 ± 13 years. The mean of hemoglobin level was 7.7 ± 1.9 g/dL in Hb SS patients versus 11.27 ± 1.79 g/dL in Hb SC patients (p = 0.001). The mean leukocyte count was 13.2 ± 4.4 G/L in Hb SS patients versus 7.3 ± 3 G/L in Hb SC patients (p = 0.003); the mean neutrophil count was 6.93 ± 3.24 G/L in Hb SS patients versus 3.96 ± 1.72 G/L in Hb SC patients (p = 0.001). Platelet counts averaged 426 ± 213 G/L in Hb SS patients versus 223 ± 103 G/L in Hb SC patients (p = 0.001).
 Conclusion: This study revealed a higher mean hemoglobin level, mean leukocyte count and mean platelet count in Hb SS patients compared to Hb SC patients in the stationary phase.