Hematological parameters in streptozotocin-induced diabetic rats and the effect of Rosa damascena Mills. extract

Abstract

Introduction: Chronic inflammation is the primary factor contributing to the development of diabetes mellitus and its associated problems in affected patients. White blood cells are of significant importance in the degenerative mechanism of blood vessel walls in individuals with diabetes, ultimately leading to the development of atherosclerosis and initiating the rupture of unstable plaques, which subsequently causes thrombosis. Red roses contain anthocyanins, with cyanidin being the specific compound that demonstrates the greatest antioxidant action. The main aim of this study was to investigate the impact of various doses of ethanol extract derived from Rosa Damascena on hematological markers in rats with diabetes. Methods: This study used an experimental design with a randomized post-test-only control group. A total of twenty male Wistar rats were allocated into five distinct groups for the purpose of this study. The groups were categorized as follows: Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group, which was further separated into three subgroups denoted as P1 (250 mg/kgBW), P2 (500 mg/kgBW), and P3 (1,000 mg/kgBW). The experimental groups received a single injection of streptozotocin at a dosage of 50 mg/kgBW to induce diabetes. Additionally, they were administered oral treatment of Rosa Damascena ethanolic extract for a duration of 2 weeks. Results: The group denoted as P2 has the lowest NLR, as seen by a mean value of 0.06. In contrast, the group administered with Metformin exhibited the lowest leukocyte value, with a mean of 7.98±6.0. Nevertheless, there are no substantial disparities in the remaining variables. Conclusion: The results of this study indicate that the ethanol extract obtained from Rosa Damascena did not have a statistically significant effect on the hematological parameters of rats with streptozotocin-induced diabetes.