Hematological malignancies: Incidence in Basse-Normandie, France, for 1997–2004

Abstract

Background This study was designed to present the incidence of all the hematological malignancies in Basse-Normandie for 1997–2004. We extracted the data from the Registre régional des hémopathies malignes de Basse-Normandie (RRHMBN), a French registry which belongs to the Association of the French Cancer Registries (FRANCIM). Methods All the malignant hematological diseases were coded using the third edition of the International Classification for Oncologic Diseases (ICDO-3) and the ADICAP classification, a special version adapted in 2001 for hematology. A total of 5510 new cases of malignant hematological disorders were registered over the 1997–2004 period. No significant difference in incidence was detected for any of the departments making up the Basse-Normandie region (Calvados, Manche and Orne). In men, the most frequent malignant disorders were non-Hodgkin malignant lymphomas (NHML) followed by chronic lymphocytic leukemia and other mature neoplasms, myelodysplastic syndromes (MDS), multiple myelomas (MM), myeloproliferative syndromes (MPS), acute myeloid leukemias (AML), Hodgkin lymphomas (HL), Waldenström macroglobulinemia (WM), and acute lymphoblastic leukemia (ALL). In women, MM is the third most frequent hematological disorder after NHML and lymphocytic leukemia followed by other mature neoplasms, MPS, MDS, AML, HL, WM, and ALL. The other hematological disorders are very rare. Results We provide the incidence for the main hematological disorders and for the first time present the incidence of the different subtypes of the HL and NHML, mature lymphoid neoplasms, MPD, and MDS. These results are useful for the organization and follow-up of medical care. The development of specialized hematology and active protocols can optimize the management of older patients. High-quality data remain necessary for continuous monitoring and research on patients with malignant hematological diseases.