Hematological changes produced in mice by Nuvacron or Furadan

Abstract

The effects of multiple intraperitoneal doses of Nuvacron (0.8 mg/kg) or Furadan (0.25 mg/kg) on hematological values in mice were studied. The following were measured: clotting time, hemoglobin content, total count of red blood cells and white blood cells, differential count of white blood cells, platelet count, erythrocyte sedimentation rate, hematocrit value, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, bone marrow and splenic measurements. These pesticides caused a significant decrease in hemoglobin content, total count of red blood cells, platelet count, erythrocyte sedimentation rate and hematocrit value. The administration of Nuvacron and Furadan prolonged the clotting time and caused an increase in total count of white blood cells. Among white blood cells, there was an increase in neutrophils and basophils and a fall in the count of lymphocytes in treated animals. Bone marrow depression and splenic hyperplasia were observed in mice after administration of the pesticides.