Hematological Changes In Administration Of Garcina Kola Seed Extract To Wistar Rats

Abstract

In a number of ailments, hematological tests are useful in diagnosing and determining the extent of blood production. The impact of Garcina kola seed extract (G. kola) on blood parameters was investigated in this study. Twenty-five (25) adult male wistar rats (weighing 130–180 g on average) were acclimatized for two weeks before being divided into five (5) groups of five (5) rats each (n = 5). They were subsequently fed G. kola seed extract in various quantities (doses) for 21 days (3 weeks). While normal control (Group I) mice were fed standard rat chow and water ad libitum, group 2 animals were fed 100 mg/kg of test extract, while groups 3 - 5 were fed 200 mg/kg, 300 mg/kg, and 400 mg/kg of the same G.kola seed extract, respectively. Rats were venipunced, blood samples were obtained, and haematological alterations were analyzed in the laboratory after a period of administration of test chemicals. During this time, student's t-test was used to compare the connection in means between each group and the control group. P-values less than 0.05 were considered statistically significant. Finally, hematological measures such as PCV, RBC, HGB, LYM, MON, BAS, EOS, and NEU counts showed a significant effect. Oral administration of aqueous extract of G. kola seed to the mice decreased RBC and HGB levels insignificantly compared to control, while higher dose administration significantly increased PCV and HGB counts (p 0.05). In comparison to the control, lymphocyte counts were considerably (p 0.05) higher in group 4, but not in the other extract-fed groups. The counts of basophils and eosinophils, as well as neutrophils, were significantly higher than the control group, especially as the dose was raised. In rats, an extracts of G. kola raised the immune system while lowering RBC production, causing anemia and having a negligible effect on PCV and HGB. Further research into the likely molecular mechanism for this could be useful in clinical treatment, thus it is recommended.