Abstract
Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.
Highlights
Nonhuman primates (NHPs), the closest animal models to humans in terms of genetics, physiology, and behavior, play a major role in current biomedical research [1, 2]
Age exerted a significant effect on most hematological parameters, except mean platelet volume (MPV), plate volume distribution width (PDW), and platelet large cell ratio (P-LCR) (Table 1, Fig 1 and S1 Table)
The differences in the effects of sex are important in physiology and disease as they represent gender-related biological factors that may lead to enhanced prevention and therapy [30]
Summary
Nonhuman primates (NHPs), the closest animal models to humans in terms of genetics, physiology, and behavior, play a major role in current biomedical research [1, 2]. Rhesus macaques share nearly 98% of their genetic homology with humans [12], and their similarities include morphology, reproductive physiological characteristics, and biochemical metabolism They are recognized as the best and sometimes the only available experimental animals for biomedical or translational research in pharmacology and toxicology, oncology, cardiovascular disease, reproductive medicine, zoonotic transmission, and pre-clinical studies [1, 13,14,15,16,17]. Chen et al reported the routine chemistry and hematology parameters of Chinese rhesus macaques (3–5 years old, n = 36) These parameters cannot accurately reflect their physical health status because the study employed a small sample size, a limited age range, and incomplete indicators [20, 23,24,25,26]. The obtained sex- and age-based hematological and biochemical parameters are useful indicators when using rhesus macaques as an animal model
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