Hematological and biochemical parameter alteration after plateletpheresis donation

Abstract

Background The plateletpheresis process is a great improvement in transfusion medicine, and it is thought to be generally safe to the donor. However, donors’ safety issues and the anticoagulant used during these procedures have not been fully explored. This study aimed at analyzing the significance of alteration in some hematological parameters, total calcium and total magnesium levels, in donors after plateletpheresis procedure. Materials and methods The plateletpheresis procedures were performed on 72 donors. Prehematological and posthematological values were analyzed, such as hemoglobin concentration, hematocrit, platelet, white blood cell, red blood cell, mean platelet volume, and platelet distribution width, as well as measured total serum calcium (tCa 2+ ) and magnesium levels (tMg 2+ ), at different time intervals during and after the procedure in all donors. Results After plateletpheresis procedures, we observed that the hemoglobin concentration, hematocrit%, and white blood cell count were highly significantly decreased ( P P P =0.036), without significant changes in platelet distribution width and red blood cell. In addition, there were significant decrease ( P Discussion Plateletpheresis procedures are very safe for donors; however, indicated biochemical and hematological parameters before and after the donation are definitely useful to establish postdonation reference ranges that are needed for carefully monitoring, retaining and following-up the donor, reviewing the repeated donations, and to protect donation safety by looking for the cumulative effects of these changes, as well as transfusion of blood products with higher-quality needs.